Design, Synthesis, and Anti-inflammatory Activity of Novel Quinazolines
نویسنده
چکیده
Several new fluorinated quinazolinone derivatives were prepared and evaluated for in vitro anti-inflammatory activity. The molecular modelling study was performed for compounds 4, 8, 9, 10 and 13. The tested compounds showed strong interactions at the COX-2 binding sites. Compounds 8, 13, 9, and 10 containing triazole, thiadiazole, and oxadiazole rings showed the highest in vitro anti-inflammatory activity and the best binding into the COX-2 binding site.
منابع مشابه
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